Engineering signal transduction pathways.

TitleEngineering signal transduction pathways.
Publication TypeJournal Article
Year of Publication2010
AuthorsKiel, C, Yus E, Serrano L
JournalCell
Volume140
Issue1
Pagination33-47
Date Published2010 Jan 8
Abstract

Cells respond to their environment by sensing signals and translating them into changes in gene expression. In recent years, synthetic networks have been designed in both prokaryotic and eukaryotic systems to create new functionalities and for specific applications. In this review, we discuss the challenges associated with engineering signal transduction pathways. Furthermore, we address advantages and disadvantages of engineering signaling pathways in prokaryotic and eukaryotic cells, highlighting recent examples, and discuss how progress in synthetic biology might impact biotechnology and biomedicine.

DOI10.1016/j.cell.2009.12.028
Alternate JournalCell