SAPIN: a framework for the structural analysis of protein interaction networks.

TitleSAPIN: a framework for the structural analysis of protein interaction networks.
Publication TypeJournal Article
Year of Publication2012
AuthorsYang, J-S, Campagna A, Delgado J, Vanhee P, Serrano L, Kiel C
JournalBioinformatics (Oxford, England)
Volume28
Issue22
Pagination2998-9
Date Published2012 Nov 15
Abstract

Protein interaction networks are widely used to depict the relationships between proteins. These networks often lack the information on physical binary interactions, and they do not inform whether there is incompatibility of structure between binding partners. Here, we introduce SAPIN, a framework dedicated to the structural analysis of protein interaction networks. SAPIN first identifies the protein parts that could be involved in the interaction and provides template structures. Next, SAPIN performs structural superimpositions to identify compatible and mutually exclusive interactions. Finally, the results are displayed using Cytoscape Web.

DOI10.1093/bioinformatics/bts539
Alternate JournalBioinformatics