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Design of Biological Systems
  • Home
  • Research Topics
    • Mycoplasma pneumoniae
    • Cell Signaling
    • Protein Engineering
    • Synthetic Biology
    • SysteMTb
  • Software / Databases
  • Grants and Funding
  • Gallery
  • Lab in the Media
  • Former Members
  • Contact us
  • Back to the Official Group Page

Member Profile

Jae-Seong Yang

Biography

 

EDUCATIONAL BACKGROUND:

M.S.-Ph.D. integrated course (Mar 2006 - Feb 2012)

1) School of Interdisciplinary Bioscience and Bioengineering, POSTECH, Pohang, Republic of Korea

 

B.S. (Mar 1998 - Feb 2006)

1) Department of Life Science, POSTECH, Pohang, Republic of Korea

2) Department of Computer Science, POSTECH, Pohang, Republic of Korea (double major)

3) Skilled Industry Personnel at Substitute Military Service, Seoul, Republic of Korea (Jan 2002 - Jan 2005)

 

RESEARCH EXPERIENCES:

M.S.-Ph.D. student, Structural Bioinformatics Laboratory (Mar 2006 - Feb 2012), School of Interdisciplinary Bioscience and Bioengineering, POSTECH, Pohang, Republic of Korea

 

Post-doctoral researcher, Serrano Lab (Apr 2012 - present), Systems Biology Unit, CRG Barcelona, Spain.

 

WORK EXPERIENCE:

Softdigm (Jan 2002 - Dec 2004), Online analytical processing (OLAP) tool development, Software engineer as a Skilled Industry Personnel at Substitute Military Service

 

Handysoft (Jan 2004 - Jan 2005), Groupware client development, Software engineer as a Skilled Industry Personnel at Substitute Military Service

 

Daum Communications Corp (Jan 2005 - Feb 2005), one of the biggest internet media companies in Korea, Freelancer Software engineer

 

Resume

PUBLICATIONS:

Kiel C., Verschueren E., Yang JS, Serrano L. Integration of protein abundance and structure data reveals competition in the ErbB signaling network. Sci Signal., 2013 Dec 17;6(306):ra109. doi: 10.1126/scisignal.2004560.

 

Park JH*, Park S*, Yang JS, Kwon OS, Kim S+, Jang SK+.: Discovery of Cellular Proteins Required for the Early Steps of HCV Infection Using Integrative Genomics., PLoS One. 2013 Apr 12;8(4):e60333. Print 2013. (*equal contribution)

 

Yang JS, Kim J, Park S, Jeon J, Shin YE, Kim S.: Spatial and functional organization of mitochondrial protein network., Scientific Reports 2013;3:1403. doi: 10.1038/srep01403.   

 

Seo SW*, Yang JS*, Kim I, Yang J, Min BE, Kim S+, Jung GY+: Predictive design of mRNA translation initiation region to control prokaryotic translation efficiency, Metabolic Engineering

Available online 17 November 2012 (*equal contribution)

 

Park S, Yang JS, Kim J, Shin YE, Hwang J, Park J, Jang SK, Kim S: Evolutionary history of human disease genes reveals phenotypic connections and comorbidity among genetic diseases, Scientific Reports 2, Article number: 757 

 

Yang JS, Campagna A, Delgado J, Vanhee P, Serrano L+, Kiel C+: SAPIN: Structural Analysis for Protein Interaction Networks, Bioinformatics, 2012 Sept

 

Yang JS*, Seo SW*, Jang S, Jung GY+, Kim S+: Rational Engineering of Enzyme Allosteric Regulation through Sequence Evolution Analysis, PLoS Comput Biol. 2012 July; 8(7): e1002612. doi:10.1371/journal.pcbi.1002612 (*equal contribution)

 

Kim J, Kim I, Yang JS, Shin YE, Hwang J, Kim S: Rewiring of PDZ domain-ligand interaction network contributed to eukaryotic evolution, PLoS Genet. 2012 Feb;8(2):e1002510. Epub 2012 Feb 9. (PMID: 22346764)

 

Choi DS* , Yang JS*, Choi EJ*, Jang SC, Park S,  Kim OY, Hwang D, Kim KP, Kim YK, Kim S+, Gho YS+: The protein interaction network of extracellular vesicles derived from human colorectal cancer cells, J Proteome Res. 2012 Feb 3;11(2):1144-51. Epub 2012 Jan 9. (PMID: 22149170) (*equal contribution)

 

Cho NH, Cheong TC, Min JH, Wu JH, Lee SJ, Kim D, Yang JS, Kim S, Kim YK, Seong SY: A multifunctional core-shell nanoparticle for dendritic cell-based cancer immunotherapy. Nature Nanotechnology 2011;6(10). (PMID: 21909083) 

 

Yang JS, Nam HJ, Seo M, Han SK, Choi Y, Nam HG, Lee SJ, Kim S. OASIS: Online Application for the Survival Analysis of Lifespan Assays Performed in Aging Research, PLoS ONE 2011;6(8):e23525. (PMID: 21858155)

 

Jeon J, Jeong JH, Baek JH, Koo HJ, Park WH, Yang JS, Yu MH, Kim S, Pak YK: Network clustering revealed the systemic alterations of mitochondrial protein expression. PLoS Computational Biology 2011, 7(6):e1002093 (PMID: 21738461)

 

Park S, Yang JS, Shin YE, Park J, Jang SK, et al. (2011) Protein localization as a principal feature of the etiology and comorbidity of genetic diseases. Mol Syst Biol 7: 494. (PMID: 21613983)

 

Jeon J, Nam HJ, Choi Y, Yang JS, Hwang J, Kim S: Molecular evolution of protein conformational changes revealed by a network of evolutionarily-coupled residues. Mol Biol Evol 2011. (PMID: 21470969)

 

Yang JS*, Kim JT*, Jeon J, Park HS, Kang GH, Park KS, Lee HK, Kim S, Cho YM: Changes in hepatic gene expression upon oral administration of taurine-conjugated ursodeoxycholic acid in ob/ob mice. PLoS One 2010, 5(11):e13858. (*equal contribution) (PMID: 21079772)

 

Lee GH, Ahn T, Kim DS, Park SJ, Lee YC, Yoo WH, Jung SJ, Yang JS, Kim S, Muhlrad A et al: Bax inhibitor 1 increases cell adhesion through actin polymerization: involvement of calcium and actin binding. Mol Cell Biol 2010, 30(7):1800-1813. (PMID: 20123969)

 

Choi YS, Han SK, Kim J, Yang JS, Jeon J, Ryu SH, Kim S: ConPlex: a server for the evolutionary conservation analysis of protein complex structures. Nucleic Acids Res 2010, 38(Web Server issue):W450-456. (PMID: 20435678)

 

Cho BA, Cho NH, Min CK, Kim SY, Yang JS, Lee JR, Jung JW, Lee WC, Kim K, Lee MK et al: Global gene expression profile of Orientia tsutsugamushi. Proteomics 2010, 10(8):1699-1715. (PMID: 20186754)

 

Park S, Yang JS, Jang SK, Kim S: Construction of functional interaction networks through consensus localization predictions of the human proteome. J Proteome Res 2009, 8(7):3367-3376. (PMID: 19415893)

 

Jeon J, Yang JS, Kim S: Integration of evolutionary features for the identification of functionally important residues in major facilitator superfamily transporters. PLoS Comput Biol 2009, 5(10):e1000522. (PMID: 19798434)

 

Choi YS, Yang JS, Choi Y, Ryu SH, Kim S: Evolutionary conservation in multiple faces of protein interaction. Proteins 2009, 77(1):14-25. (PMID: 19350617)

 

Min CK, Yang JS, Kim S, Choi MS, Kim IS, Cho NH: Genome-based construction of the metabolic pathways of Orientia tsutsugamushi and comparative analysis within the Rickettsiales order. Comp Funct Genomics 2008:623145. (PMID: 18528528)

 

Min CK, Bang SY, Cho BA, Choi YH, Yang JS, Lee SH, Seong SY, Kim KW, Kim S, Jung JU et al: Role of amphipathic helix of a herpesviral protein in membrane deformation and T cell receptor downregulation. PLoS Pathog 2008, 4(11):e1000209. (PMID: 19023411)

 

Choi S, Jeon J, Yang JS, Kim S: Common occurrence of internal repeat symmetry in membrane proteins. Proteins 2008, 71(1):68-80. (PMID: 17932930)

 

Kim YK, Park HW, Yang JS, Oh SY, Chang YS, Shin ES, Lee JE, Kim S, Gho YS, Cho SH et al: Association and functional relevance of E237G, a polymorphism of the high-affinity immunoglobulin E-receptor beta chain gene, to airway hyper-responsiveness. Clin Exp Allergy 2007, 37(4):592-598. (PMID: 17430357)


Jae-Seong Yang
Jae-Seong.yang@crg.eu
Postdoctoral Researcher
507.02
+34 93 316 0258
Group Members

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