Member Profile
Javier Delgado
Biography
WORK EXPERIENCE:
2010-currently: Post Doctoral position at CRG Barcelona, Spain. Project: FoldX, fragment libraries integration. Mycoplasma transposon data Analysis.
2008-2010: Post Doctoral position at VIB/VUB Brussels, Belgium. Project: Parallelization of FoldX, Parameterization of non-natural aminoacids, FoldX guided Antibody Design, Prediction of Transmembrane Helix interactions. “InSilico Batabase”: a database of microarray afymetrix data from cancer cells.
2006-2007: C++ on UNIX analyst on R&D project at Telefonica I+D, Madrid, Spain. July 2007. Project: Sistema Integrado de Gestion de ADSL, SIGA.
2005: C++/pro*C/SQL Senior Programmer on R&D project at Santander´s Bank, Madrid, Spain. Project: Sistema Integrado de Inversiones, SII.
2001-2005: Organic Chemistry. PhD student at Dr. Francisco Amat-Guerri and Dr. A. Ulises Acuña lab. Instituto de Química Orgánica General (CSIC) and Instituto de Química-Física Rocasolano (CSIC), Madrid, Spain.
2000-2001: Student collaborator. Instituto de Química Orgánica General (Department of Synthesis, CSIC) and Instituto de Química-Física Rocasolano (Deparment of Biophysics, CSIC), Madrid, Spain.
Resume
PUBLICATIONS:
2014: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. "Creating stable stem regions for loop elongation in Fcabs — Insights from combining yeast surface display, in silico loop reconstruction and molecular dynamics simulations". Christoph Hasenhindl, Balder Lai, Javier Delgado, Michael W. Traxlmayr, Gerhard Stadlmayr, Florian Rüker, Luis Serrano, Chris Oostenbrink, Christian Obinger.
2013: Journal of Biological Chemistry. "Drug uptake, lipid rafts and vesicle trafficking modulate resistance to an anticancer lysophosphatidylcholine analogue in yeast". Alvaro Cuesta-Marbán, Javier Botet, Ola Czyz, Luis M. Cacharro, Consuelo Gajate, Valentín Hornillos, Javier Delgado, Hui Zhang, Francisco Amat-Guerri, A. Ulises Acuña, Christopher R. McMaster, Jose Luis Revuelta, Vanina Zaremberg, Faustino Mollinedo.
2012: Plos Genetics. "Comprehensive Methylome Characterization of Mycoplasma genitalium and Mycoplasma pneumoniae at Single-Base Resolution". Maria Lluch-Senar, Khai Luong, Verónica Lloréns-Rico, Javier Delgado, Gang Fang, Kristi Spittle, Tyson A. Clark, Eric Schadt, Stephen W. Turner, Jonas Korlach, Luis Serrano.
2012: Molecular systems biology. "Transcription start site associated RNAs in bacteria". Eva Yus, Marc Güell, Ana P Vivancos, Wei-Hua Chen, María Lluch-Senar, Javier Delgado, Anne-Claude Gavin, Peer Bork, Luis Serrano.
2012: Bioinformatics. “SAPIN: Structural Analysis for Protein Interaction Networks”. Jae-Seong Yang, Anne Campagna, Javier Delgado, Peter Vanhee, Luis Serrano, Christina Kiel.
2011: PLoS Computational Biology. “An Evolutionary Trade-Off between Protein Turnover Rate and Protein Aggregation Favors a Higher Aggregation Propensity in Fast Degrading Proteins”. Greet De Baets, Joke Reumers, Javier Delgado Blanco, Joaquin Dopazo, Joost Schymkowitz, Frederic Rousseau.
2011: Cell Death and Disease. “Involvement of lipid rafts in the localization and dysfunction effect of the antitumor ether phospholipid edelfosine in mitochondria”. F. Mollinedo, M. Fernández, V. Hornillos, J. Delgado, F. Amat-Guerri, A. U. Acuña, T. Nieto-Miguel, J.A. Villa-Pulgarín, C. González-García, V. Ceña, C. Gajate.
2011: Bioinformatics. “A graphical interface for the FoldX forcefield”. Joost Van Durme, Javier Delgado, François Stricher, Luis Serrano, Joost Schymkowitz, Frederic Rousseau.
2007 European Journal of Organic Chemistry. “Synthesis and Spectral Properties of Amphiphilic Lipids with Linear Conjugated Polyene and Phenylpolyene Fluorescent Groups”. Ernesto Quesada, Javier Delgado, Valentín Hornillos, A. Ulises Acuña, Francisco Amat-Guerri.
2007 Biochimica et Biophysica Acta. “The Phenyltetraene Lysophospholipid Analog PTE-ET-18-OMe as a Fluorescent Anisotropy Probe of Liquid Ordered Membrane Domains (Lipid Rafts) and Ceramide-Rich Membrane Domains”. Omar Bakht; Javier Delgado; Francisco Amat-Guerri; Ulises Acuna; Erwin London.
2007 J. Med. Chem. “Synthesis and biological evaluation of fluorescent leishmanicidal analogs of hexadecylphosphocholine (miltefosine) as probes of antiparasite mechanisms”. José M. Saugar; Javier Delgado; Valentín Hornillos; Juan R. Luque-Ortega; Francisco Amat-Guerri, A. Ulises Acuña; Luis Rivas.
2004 J. Med. Chem. “Fluorescent Phenylpolyene Analogues of the Ether Phospholipid Edelfosine for the Selective Labeling of Cancer Cells”. Ernesto Quesada, Javier Delgado, Consuelo Gajate, Faustino Mollinedo, A. Ulises Acuña, Francisco Amat-Guerri.
Group Members